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  <xs:element id="zlab_DeferredTaxAssetsValuationAllowanceRollForward" abstract="true" name="DeferredTaxAssetsValuationAllowanceRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="zlab_CullinanPearlCorpMember" abstract="true" name="CullinanPearlCorpMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_TakedaPharmaceuticalCompanyLimitedMember" abstract="true" name="TakedaPharmaceuticalCompanyLimitedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_LandUseRightsLeaseTerm" abstract="false" name="LandUseRightsLeaseTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="zlab_MacroGenicsIncNovember2018AgreementMember" abstract="true" name="MacroGenicsIncNovember2018AgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_EquitySecuritiesWithReadilyDeterminableFairValueAmount" abstract="false" name="EquitySecuritiesWithReadilyDeterminableFairValueAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="zlab_EntasisTherapeuticsHoldingsIncorporationMember" abstract="true" name="EntasisTherapeuticsHoldingsIncorporationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_CashAndCashEquivalentMember" abstract="true" name="CashAndCashEquivalentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_LicensesAndCollaborativeArrangementAbstract" abstract="true" name="LicensesAndCollaborativeArrangementAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="zlab_ZaiLabTaiwanLimitedMember" abstract="true" name="ZaiLabTaiwanLimitedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="zlab_ForeignCurrencyRiskMember" abstract="true" name="ForeignCurrencyRiskMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_EffectiveIncomeTaxRateReconciliationAtPreferentialTaxRate" abstract="false" name="EffectiveIncomeTaxRateReconciliationAtPreferentialTaxRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="zlab_AccountsReceivableFromCollaborativeAgreementMember" abstract="true" name="AccountsReceivableFromCollaborativeAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_RevenueFromContractWithCustomersExcludingAssessedTaxAdjustmentsForRebatesAndSalesReturn" abstract="false" name="RevenueFromContractWithCustomersExcludingAssessedTaxAdjustmentsForRebatesAndSalesReturn" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="zlab_MacroGenicsIncMember" abstract="true" name="MacroGenicsIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_MainlandChinaGovernmentPlanMember" abstract="true" name="MainlandChinaGovernmentPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_SummaryOfWeightedAverageRemainingLeaseTermsAndDiscountRatesTableTextBlock" abstract="false" name="SummaryOfWeightedAverageRemainingLeaseTermsAndDiscountRatesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
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  <xs:element id="zlab_KarunaTherapeuticsIncMember" abstract="true" name="KarunaTherapeuticsIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_AmericanDepositaryShareToCommonStockConversionRatio" abstract="false" name="AmericanDepositaryShareToCommonStockConversionRatio" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="zlab_NuzyraMember" abstract="true" name="NuzyraMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_SignificantAccountingPoliciesTable" abstract="true" name="SignificantAccountingPoliciesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
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  <xs:element id="zlab_DecipheraPharmaceuticalsLLCMember" abstract="true" name="DecipheraPharmaceuticalsLLCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_DefinedContributionPlanEmployerMatchingContributionPercentOfEmployeeContribution" abstract="false" name="DefinedContributionPlanEmployerMatchingContributionPercentOfEmployeeContribution" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
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  <xs:element id="zlab_SeagenIncMember" abstract="true" name="SeagenIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_MiratiTherapeuticsIncMember" abstract="true" name="MiratiTherapeuticsIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_CollaborativeArrangementRightsAndObligationsAlternativeProfitShareArrangementPercentage" abstract="false" name="CollaborativeArrangementRightsAndObligationsAlternativeProfitShareArrangementPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
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  <xs:element id="zlab_CollaborativeArrangementRightsAndObligationsDevelopmentMilestonePayment" abstract="false" name="CollaborativeArrangementRightsAndObligationsDevelopmentMilestonePayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="zlab_IncomeLossFromEquityMethodInvestmentsNetOfTax" abstract="false" name="IncomeLossFromEquityMethodInvestmentsNetOfTax" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="zlab_CollaborativeArrangementRightsAndObligationsNumberOfPrograms" abstract="false" name="CollaborativeArrangementRightsAndObligationsNumberOfPrograms" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="zlab_ElectronicEquipmentMember" abstract="true" name="ElectronicEquipmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_GlaxoSmithKlineMember" abstract="true" name="GlaxoSmithKlineMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_AccruedRebateToDistributorsCurrent" abstract="false" name="AccruedRebateToDistributorsCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="zlab_IssuanceCostAdjustment" abstract="false" name="IssuanceCostAdjustment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="zlab_EmployeeTaxesPaidRelatedToSettlementOfEquityAwards" abstract="false" name="EmployeeTaxesPaidRelatedToSettlementOfEquityAwards" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="zlab_ShareBasedPaymentArrangementOptionBatchThreeMember" abstract="true" name="ShareBasedPaymentArrangementOptionBatchThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_SupplementalInformationRelatedToLeasesTableTableTextBlock" abstract="false" name="SupplementalInformationRelatedToLeasesTableTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
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  <xs:element id="zlab_ZaiLabHongKongAndZlChinaHoldingTwoAndZaiAutoImmuneHongKongAndZaiAntiInfectivesHongKongLimitedMember" abstract="true" name="ZaiLabHongKongAndZlChinaHoldingTwoAndZaiAutoImmuneHongKongAndZaiAntiInfectivesHongKongLimitedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="zlab_CrescendoBiologicsLtdMember" abstract="true" name="CrescendoBiologicsLtdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_LandUseRightsNetNoncurrent" abstract="false" name="LandUseRightsNetNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="zlab_TwoThousandTwentyTwoEquityIncentivePlanMember" abstract="true" name="TwoThousandTwentyTwoEquityIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_ShareBasedPaymentArrangementTrancheFiveMember" abstract="true" name="ShareBasedPaymentArrangementTrancheFiveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_AmgenMember" abstract="true" name="AmgenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_DeferredTaxAssetsPublicWelfareDonations" abstract="false" name="DeferredTaxAssetsPublicWelfareDonations" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="zlab_IncreaseDecreaseInOperatingLeaseLiabilities" abstract="false" name="IncreaseDecreaseInOperatingLeaseLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="zlab_RelatedPartyTransactionResearchAndDevelopmentExpensesMember" abstract="true" name="RelatedPartyTransactionResearchAndDevelopmentExpensesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="zlab_PayablesForPurchaseOfPropertyAndEquipmentCurrent" abstract="false" name="PayablesForPurchaseOfPropertyAndEquipmentCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="zlab_A401kPlanMember" abstract="true" name="A401kPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="zlab_CollaborativeArrangementRightsAndObligationsPaymentOfUpFrontFeesForLicenseAgreement" abstract="false" name="CollaborativeArrangementRightsAndObligationsPaymentOfUpFrontFeesForLicenseAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="zlab_LossOnFairValueChangesOfEquityInvestmentWithReadilyDeterminableFairValue" abstract="false" name="LossOnFairValueChangesOfEquityInvestmentWithReadilyDeterminableFairValue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="zlab_CollaborativeArrangementRightsAndObligationsDevelopmentCostSharingPayment" abstract="false" name="CollaborativeArrangementRightsAndObligationsDevelopmentCostSharingPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="zlab_ParatekBermudaLimitedMember" abstract="true" name="ParatekBermudaLimitedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_LaboratoryEquipmentMember" abstract="true" name="LaboratoryEquipmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_RevenueFromContractWithCustomersExcludingAssessedTaxBeforeAdjustmentsForRebatesAndSalesReturn" abstract="false" name="RevenueFromContractWithCustomersExcludingAssessedTaxBeforeAdjustmentsForRebatesAndSalesReturn" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="zlab_BlueprintMedicinesCorporationMember" abstract="true" name="BlueprintMedicinesCorporationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="zlab_CollaborativeArrangementRightsAndObligationsNumberOfMilestonePayments" abstract="false" name="CollaborativeArrangementRightsAndObligationsNumberOfMilestonePayments" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="zlab_MacroGenicsIncJune2021AgreementMember" abstract="true" name="MacroGenicsIncJune2021AgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_MajorSuppliersAxis" abstract="true" name="MajorSuppliersAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
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  <xs:element id="zlab_ZaiLabInternationalTradingShanghaiCompanyLimitedMember" abstract="true" name="ZaiLabInternationalTradingShanghaiCompanyLimitedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="zlab_CollaborativeArrangementRightsAndObligationsSalesBasedMilestonePayment" abstract="false" name="CollaborativeArrangementRightsAndObligationsSalesBasedMilestonePayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="zlab_ResearchAndDevelopmentExpensesAndTheInventoryPurchases" abstract="false" name="ResearchAndDevelopmentExpensesAndTheInventoryPurchases" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="zlab_NovocureLimitedMember" abstract="true" name="NovocureLimitedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="zlab_IncomeTaxesTable" abstract="true" name="IncomeTaxesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="zlab_ZaiLabAUSTPtyLtdMember" abstract="true" name="ZaiLabAUSTPtyLtdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_ZaiLabTradingSuzhouCoLtdMember" abstract="true" name="ZaiLabTradingSuzhouCoLtdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_ThresholdAnnualIncreaseToTheNumberOfOrdinarySharesReservedToPercentageOfNumberOfOrdinarySharesOutstanding" abstract="false" name="ThresholdAnnualIncreaseToTheNumberOfOrdinarySharesReservedToPercentageOfNumberOfOrdinarySharesOutstanding" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="zlab_ZaiLabSuzhouCompanyLimitedMember" abstract="true" name="ZaiLabSuzhouCompanyLimitedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_ADRProgramReimbursementsMember" abstract="true" name="ADRProgramReimbursementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_NotesReceivablePolicyTextBlock" abstract="false" name="NotesReceivablePolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="zlab_IncreaseDecreaseInLongTermDeposits" abstract="false" name="IncreaseDecreaseInLongTermDeposits" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="zlab_MandatoryProvidentFundMember" abstract="true" name="MandatoryProvidentFundMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_ZaiLabShanghaiCompanyLimitedMember" abstract="true" name="ZaiLabShanghaiCompanyLimitedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_ShareBasedPaymentArrangementOptionBatchTwoMember" abstract="true" name="ShareBasedPaymentArrangementOptionBatchTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="zlab_CollaborativeArrangementRightsAndObligationsNumberOfUpFrontPayments" abstract="false" name="CollaborativeArrangementRightsAndObligationsNumberOfUpFrontPayments" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
</xs:schema>
