Regeneron Resumes Enrollment of FL and DLBCL Patients in Odronextamab Trials
Regeneron is resuming enrollment of patients with follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) in its monotherapy trials of odronextamab, a CD20xCD3 bispecific antibody, following agreement with the U.S. Food and Drug
Administration to lift the partial clinical trial hold for those patient cohorts. Trial protocols have been amended to further reduce the incidence of ≥Grade 3 cytokine release syndrome during step-up dosing. Regeneron will recommence enrollment in these patient cohorts effective immediately (trials NCT02290951 and NCT03888105).
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